Designed and Developed in the UK

Smart packaging shows you what happened during shipment.

Integrate Holtronic neo® electronic indicators directly into your packaging, from primary blister packs to insulated shippers, and transform every unit you send into a self-monitoring, self-documenting smart package with visible LED alerts and wireless data transfer.

The Smart Packaging Opportunity

Smart Packaging – a growth market driven by cold chain demand

The market for smart packaging in cold chain logistics is growing rapidly, driven by tightening pharmaceutical regulations, expanding e-commerce of perishables and rising consumer expectation of product integrity evidence. Electronic temperature indicators are at the centre of this shift, from passive packaging that simply contains, to active packaging that monitors, communicates and documents.

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Integration In Practice

From packaging line to smart packages: three approaches.

Holtronic neo® indicators are designed for straightforward integration at multiple points in the packaging process. The method depends on the packaging format, the volume of units and whether monitoring is intended to be visible externally or accessed wirelessly.

1. Inline Packaging Line Integration

packing manufacturing temperature indicator pharmaceuticals

Activate and apply at the packing station — no secondary operation

The most efficient integration method for high-volume pharmaceutical and food operations is inline application at the packaging line. The Holtronic neo® indicator is activated and applied to the product or packaging at the same packing station where the product is cartonised, filled or sealed. Monitoring begins at exactly the moment the product is packaged, without a separate downstream operation.

The self-adhesive backing on every neo® indicator makes inline application fast and reliable. Activation is a single press-and-hold that takes under five seconds adding negligible time to the packing cycle. For even higher throughput, Holtronic works with packaging machinery manufacturers to specify automated application and activation systems.

  • Activated and applied at the packing station in a single operation
  • Self-adhesive backing — no tools, glue or secondary operation required.
  • Press-and-hold activation adds under 5 seconds per unit
  • 30-minute start delay prevents false readings from packing line handling
  • Compatible with high-volume pharmaceutical and food packing environments
2. Window & Die-Cut Packaging Design

GLP1 injector pen temperature monitor medical pharmaceutical packaging integration

Design the LED display into the packaging — visible without opening

For primary and secondary packaging where the temperature status should be readable without opening the pack — by pharmacists at goods receiving, by clinicians at the point of care, or by consumers before use — the packaging can be designed with a die-cut window or transparent panel aligned with the neo® indicator’s LED display.

This transforms the packaging itself into the user interface for the monitoring system. The LED array is visible through the window at a glance — no opening, no reader device, no app. A green-only display confirms the product has remained within its temperature range throughout the journey. Any additional LED immediately communicates what happened and when.

  • Die-cut window or transparent panel aligned with the LED face
  • LED status visible to anyone without opening the pack
  • Suitable for folding cartons, blister packs, wallet cards and sachets
  • Holtronic provides indicator dimensions and LED positioning for packaging designers
  • Can be integrated alongside existing barcode, QR and branding areas
3.Sealed Packaging — Contactless Data Retrieval

exterior packaging monitor, temperature monitoring for truck shipments and warehouses

Monitor sealed containers — retrieve data through the packaging wall

For hermetically sealed insulated shippers, validated cold boxes and packaging where opening before delivery is not possible or desirable, the neo® Blu provides a contactless solution. Positioned inside the sealed pack, the neo® Blu transfers its complete temperature log through the packaging material wirelessly. Without opening, without cables and without any network connectivity.

The receiving pharmacist, logistics supervisor or quality manager simply brings a smartphone close to the outside of the sealed package. The Holtronic app connects, showing the full breach history report within seconds before the pack is opened. This enables evidence-based acceptance or rejection decisions at the point of delivery, not hours later after the cold chain has already been broken.

  • neo® Blu positioned inside sealed shipper at dispatch
  • Wireless transfer through sealed packaging wall — no opening required
  • Full breach history downloaded to smartphone before pack is opened
  • Enables evidence-based acceptance decisions at point of delivery
  • Data report generated for compliance documentation

Choose Your Indicator

The right temperature indicator for your packaging

The neo® indicators cover every smart packaging application across primary, secondary, transit and reusable packaging. Selecting the right one depends on packaging format, monitoring requirement and data retrieval method.

Penta single use indicar
neo® Penta
Single-Use Indicators. 5 LED Alerts.
Neo Penta
neo multi reusable temperature indicators
neo® Multi
Reusable temperature indicators. Best for reusable & return-to-base packaging.
Neo Multi
neo® Blu
Wireless Temperature Data. Best for sealed & insulated packaging.
Neo Blu
neo tti. time temperature indicator
neo® TTI
Time-Temperature Integrator. Best for biologics & shelf-life packaging.
Neo TTI

Every layer of your packaging. One indicator range.

Holtronic neo® indicators are compact, self-adhesive and available in configurations tailored to the specific monitoring requirements of each packaging level from individual product cartons to bulk transit shippers.

Choose Integration

Primary Packaging →

Primary packaging integration places the indicator inside the immediate packaging of the product. At just 6g and compact enough to fit within a standard pharmaceutical carton, the neo® Penta can be affixed to or integrated into consumer products, inserted into pharmaceutical packaging, or incorporated into a blister pack design.

A die-cut window on the packaging allows the LED display to be read without opening — providing consumers, pharmacists and receiving staff with visible temperature evidence at the point of use.

Packaging formats

Product integration

Folding cartons

Wallet cards

Rigid trays

Pouches

Neo Penta

Designed around your products, not the other way around

Holtronic works directly with packaging manufacturers, brand owners and product design teams to integrate Neo indicators into new and existing packaging formats. The indicator specification, integration method and threshold configuration can all be tailored to the specific requirements of the packaging and the product it contains.

📐 Packaging-specific form factor guidance
We provide technical drawings, LED positioning diagrams and integration specifications to enable packaging designers to easily incorporate neo indicators.
🌡 Custom threshold configurations
Temperature thresholds, alarm durations and LED profiles are configurable to match the specific monitoring requirements of the product.
🔁 Reusable packaging lifecycle matching
We work with packaging manufacturers to specify neo® Multi reset integration in the packaging refurbishment workflow.
🏷 Co-branding and private label
neo® indicators can be specified with client branding, private label formats and custom serial number series.

Frequently Asked Questions

Can indicators be applied at the packaging line?

Yes. Holtronic neo® indicators are designed for inline application at the packaging or fulfilment station. Activation takes under five seconds (press-and-hold), and the self-adhesive backing makes application fast and reliable without any additional tools or equipment.

A 30-minute programmable start delay ensures monitoring begins after the product is sealed and placed in cold storage, not during packing line handling. For very high-volume operations, Holtronic can work with packaging machinery manufacturers on automated application systems.

Can the threshold configuration be customised for specific products?

Yes. Temperature thresholds, alarm durations, LED configurations and time intervals are all configurable for specific product and packaging applications. Standard pharmaceutical (2–8°C), ambient (15–25°C) and food safety profiles are available off the shelf.

Custom configurations can be specified for any product with specific temperature sensitivity, from vaccine cold chains to industrial chemical storage ranges. Contact Holtronic to discuss your specific product requirements.

Is co-branding or private labelling available?

Yes. neo® indicators can be specified with client branding, private label formats and custom serial number series for packaging manufacturers and brand owners who wish to present integrated temperature monitoring as part of their own product identity.

Contact the Holtronic team to discuss co-branding and private label specifications.

Ready to make your packaging smart

Request samples of Holtronic neo® indicators in the configuration that matches your packaging application and see what a 6g addition can do for your product’s integrity and your customers’ confidence.

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